Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells

Unlike other ErbB family members, HER2 levels are maintained on the cell surface when the receptor is activated, allowing prolonged signaling and contributing to its transforming ability. Interactions between HER2, HSP90, PMCA2, and NHERF1 within specialized plasma membrane domains contribute to the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Jeong, Jaekwang, Choi, Jungmin, Kim, Wonnam, Dann, Pamela, Takyar, Farzin, Gefter, Julia V., Friedman, Peter A., Wysolmerski, John J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2019
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6341383/
https://ncbi.nlm.nih.gov/pubmed/30463939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004143
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