HER2 signaling regulates HER2 localization and membrane retention

ErbB2/HER2/Neu is a receptor tyrosine kinase that is overexpressed in 25–30% of human breast cancers, usually associated with amplification of the ERBB2 gene. HER2 has no recognized ligands and heterodimers between HER2 and EGFR (ErbB1/HER1) or HER2 and ErbB3/HER3 are important in breast cancer. Unl...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Jeong, Jaekwang, Kim, Wonnam, Kim, Lark Kyun, VanHouten, Joshua, Wysolmerski, John J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378417/
https://ncbi.nlm.nih.gov/pubmed/28369073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174849
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