PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer

In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA2) transports milk calcium. Its expression is activated in breast cancers, where high tumor levels predict increased mortality. We find that PMCA2 expression correlates with HER2 levels in breast cancers and that PMCA2 interact...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jeong, Jaekwang, VanHouten, Joshua N., Dann, Pamela, Kim, Wonnam, Sullivan, Catherine, Yu, Herbert, Liotta, Lance, Espina, Virginia, Stern, David F., Friedman, Peter A., Wysolmerski, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725473/
https://ncbi.nlm.nih.gov/pubmed/26729871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516138113
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