PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer

In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA2) transports milk calcium. Its expression is activated in breast cancers, where high tumor levels predict increased mortality. We find that PMCA2 expression correlates with HER2 levels in breast cancers and that PMCA2 interact...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Jeong, Jaekwang, VanHouten, Joshua N., Dann, Pamela, Kim, Wonnam, Sullivan, Catherine, Yu, Herbert, Liotta, Lance, Espina, Virginia, Stern, David F., Friedman, Peter A., Wysolmerski, John J.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725473/
https://ncbi.nlm.nih.gov/pubmed/26729871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516138113
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