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Posing the APC/C E3 ubiquitin ligase to orchestrate cell division

The APC/C E3 ligase controls mitosis and non-mitotic pathways through interactions with proteins that coordinate ubiquitylation. Since the discovery that the catalytic subunits of APC/C are conformationally-dynamic “cullin” and “RING” proteins, many unexpected, intricate regulatory mechanisms have e...

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Pubblicato in:Trends Cell Biol
Autori principali: Watson, Edmond R., Brown, Nicholas G., Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6340778/
https://ncbi.nlm.nih.gov/pubmed/30482618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2018.09.007
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