EM Structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown

The Anaphase Promoting Complex/Cyclosome (APC/C) is a ~1.5 MDa multiprotein E3 ligase enzyme that regulates cell division by promoting timely ubiquitin-mediated proteolysis of key cell cycle regulatory proteins. Inhibition of human APC/C(CDH1) during interphase by Early Mitotic Inhibitor 1 (EMI1) is...

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Main Authors: Frye, Jeremiah J., Brown, Nicholas G., Petzold, Georg, Watson, Edmond R., Grace, Christy R. R., Nourse, Amanda, Jarvis, Marc A., Kriwacki, Richard W., Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742808/
https://ncbi.nlm.nih.gov/pubmed/23708605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2593
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