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The ubiquitin ligase APC/C(Cdh1) puts the brakes on DNA-end resection

DNA double-strand breaks (DSBs) are highly deleterious lesions and their misrepair can promote genomic instability, a hallmark of cancer. DNA-end resection is a cell cycle-regulated mechanism that is required for the faithful repair of DSBs. We recently discovered that the anaphase-promoting complex...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cell Oncol
Hauptverfasser: Lafranchi, Lorenzo, Sartori, Alessandro A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905325/
https://ncbi.nlm.nih.gov/pubmed/27308488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2014.1000696
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