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Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation

New treatment modalities for glioblastoma multiforme (GBM) are urgently needed. Proton therapy is considered one of the most effective forms of radiation therapy for GBM. DNA alkylating agents such as temozolomide (TMZ) are known to increase the radiosensitivity of GBM to photon radiation. TMZ is a...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Boyle, Kristopher E., Boger, Dale L., Wroe, Andrew, Vazquez, Marcelo
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6339562/
https://ncbi.nlm.nih.gov/pubmed/29650288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.04.008
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