Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors

Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase II (TOP2) mediated DNA damages and causes cellular resistance to clinically used TOP2 poisons. Inhibiting TDP2 can potentially sensitize cancer cells toward TOP2 poisons. Commercial compound P10A10, to which the structure was assigned as 7...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Ribeiro, Carlos J. A., Kankanala, Jayakanth, Xie, Jiashu, Williams, Jessica, Aihara, Hideki, Wang, Zhengqiang
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6339461/
https://ncbi.nlm.nih.gov/pubmed/30522956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.11.044
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