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Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors
Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase II (TOP2) mediated DNA damages and causes cellular resistance to clinically used TOP2 poisons. Inhibiting TDP2 can potentially sensitize cancer cells toward TOP2 poisons. Commercial compound P10A10, to which the structure was assigned as 7...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6339461/ https://ncbi.nlm.nih.gov/pubmed/30522956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.11.044 |
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