Chronic ethanol-mediated hepatocyte apoptosis links to decreased TET1 and 5-hydroxymethylcytosine formation

The 5-hydroxymethylcytosine (5hmc) is a newly identified epigenetic modification thought to be regulated by the TET family of proteins. Little information is available about how ethanol consumption may modulate 5hmC formation and alcoholic liver disease (ALD) progression. A rat ALD model was used to...

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Gepubliceerd in:FASEB J
Hoofdauteurs: Ji, Chengcheng, Nagaoka, Katsuya, Zou, Jing, Casulli, Sarah, Lu, Shaolei, Cao, Kevin Y., Zhang, Hongyu, Iwagami, Yoshifumi, Carlson, Rolf I., Brooks, Keri, Lawrence, Jonathan, Mueller, William, Wands, Jack R., Huang, Chiung-Kuei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Federation of American Societies for Experimental Biology 2019
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338639/
https://ncbi.nlm.nih.gov/pubmed/30188753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800736R
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