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Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis
OBJECTIVES: Given the role of growth and differentiation factor 5 (GDF5) in knee development and osteoarthritis risk, we sought to characterise knee defects resulting from Gdf5 loss of function and how its regulatory regions control knee formation and morphology. METHODS: The brachypodism (bp) mouse...
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| Veröffentlicht in: | Ann Rheum Dis |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6338229/ https://ncbi.nlm.nih.gov/pubmed/29311146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2017-212475 |
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