Joint disease-specificity at the regulatory base-pair level

Given the pleiotropic nature of coding sequences and that many loci exhibit multiple disease associations, it is within non-coding sequence that disease-specificity likely exists. Here, we focus on joint disorders, finding among replicated loci, that GDF5 exhibits over twenty distinct associations,...

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Publicat a:Nat Commun
Autors principals: Muthuirulan, Pushpanathan, Zhao, Dewei, Young, Mariel, Richard, Daniel, Liu, Zun, Emami, Alireza, Portilla, Gabriela, Hosseinzadeh, Shayan, Cao, Jiaxue, Maridas, David, Sedlak, Mary, Menghini, Danilo, Cheng, Liangliang, Li, Lu, Ding, Xinjia, Ding, Yan, Rosen, Vicki, Kiapour, Ata M., Capellini, Terence D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260791/
https://ncbi.nlm.nih.gov/pubmed/34230488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24345-9
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