Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk

During human evolution, the knee adapted to the biomechanical demands of bipedalism by altering chondrocyte developmental programs. This adaptive process was likely not without deleterious consequences to health. Today, osteoarthritis occurs in 250 million people, with risk variants enriched in non-...

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Publicado en:Cell
Autores principales: Richard, Daniel, Liu, Zun, Cao, Jiaxue, Kiapour, Ata M., Willen, Jessica, Yarlagadda, Siddharth, Jagoda, Evelyn, Kolachalama, Vijaya B., Sieker, Jakob T., Chang, Gary H., Muthuirulan, Pushpanathan, Young, Mariel, Masson, Anand, Konrad, Johannes, Hosseinzadeh, Shayan, Maridas, David E., Rosen, Vicki, Krawetz, Roman, Roach, Neil, Capellini, Terence D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179902/
https://ncbi.nlm.nih.gov/pubmed/32220312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.02.057
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