Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk

During human evolution, the knee adapted to the biomechanical demands of bipedalism by altering chondrocyte developmental programs. This adaptive process was likely not without deleterious consequences to health. Today, osteoarthritis occurs in 250 million people, with risk variants enriched in non-...

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Vydáno v:Cell
Hlavní autoři: Richard, Daniel, Liu, Zun, Cao, Jiaxue, Kiapour, Ata M., Willen, Jessica, Yarlagadda, Siddharth, Jagoda, Evelyn, Kolachalama, Vijaya B., Sieker, Jakob T., Chang, Gary H., Muthuirulan, Pushpanathan, Young, Mariel, Masson, Anand, Konrad, Johannes, Hosseinzadeh, Shayan, Maridas, David E., Rosen, Vicki, Krawetz, Roman, Roach, Neil, Capellini, Terence D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179902/
https://ncbi.nlm.nih.gov/pubmed/32220312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.02.057
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