Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height

GWAS have identified hundreds of height-associated loci. However, determining causal mechanisms is challenging, especially since height-relevant tissues (e.g. growth plates) are difficult to study. To uncover mechanisms by which height GWAS variants function, we performed epigenetic profiling of mur...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Guo, Michael, Liu, Zun, Willen, Jessie, Shaw, Cameron P, Richard, Daniel, Jagoda, Evelyn, Doxey, Andrew C, Hirschhorn, Joel, Capellini, Terence D
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2017
Ämnen:
Genomics and Evolutionary Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716665/
https://ncbi.nlm.nih.gov/pubmed/29205154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29329
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