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Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk
Variants in GDF5 are associated with human arthritis and height reduction, but the causal mutations are still unknown. We surveyed GDF5 for regulatory regions in transgenic mice, and fine-mapped separate enhancers controlling expression in joints versus growing ends of long bones. A large downstream...
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| Publicado no: | Nat Genet |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6556117/ https://ncbi.nlm.nih.gov/pubmed/28671685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3911 |
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