Llwytho...
Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk
Variants in GDF5 are associated with human arthritis and height reduction, but the causal mutations are still unknown. We surveyed GDF5 for regulatory regions in transgenic mice, and fine-mapped separate enhancers controlling expression in joints versus growing ends of long bones. A large downstream...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Nat Genet |
|---|---|
| Prif Awduron: | , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2017
|
| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6556117/ https://ncbi.nlm.nih.gov/pubmed/28671685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3911 |
| Tagiau: |
Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
|