Functional Analysis of the Osteoarthritis Susceptibility–Associated GDF5 Regulatory Polymorphism

OBJECTIVE: Single-nucleotide polymorphism (SNP) rs143383 (T to C) in the 5′-untranslated region (5′-UTR) of GDF5 has recently been reported to be associated with osteoarthritis (OA) susceptibility, with lower expression of the risk-associated T allele observed in vitro and in vivo. The in vivo studi...

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Veröffentlicht in:Arthritis Rheum
Hauptverfasser: Egli, Rainer J., Southam, Lorraine, Wilkins, James M., Lorenzen, Inken, Pombo-Suarez, Manuel, Gonzalez, Antonio, Carr, Andrew, Chapman, Kay, Loughlin, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6860363/
https://ncbi.nlm.nih.gov/pubmed/19565498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24616
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