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Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy

Failure of neural tube closure results in severe birth defects and can be induced by high glucose levels resulting from maternal diabetes. MARCKS is required for neural tube closure, but the regulation and of its biological activity and function have remained elusive. Here, we show that high materna...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Yang, Penghua, Xu, Cheng, Reece, E. Albert, Chen, Xi, Zhong, Jianxiang, Zhan, Min, Stumpo, Deborah J., Blackshear, Perry J., Yang, Peixin
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336777/
https://ncbi.nlm.nih.gov/pubmed/30655546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08268-6
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