Endoplasmic Reticulum Stress-Induced CHOP Inhibits PGC-1α and Causes Mitochondrial Dysfunction in Diabetic Embryopathy

Endoplasmic reticulum (ER) stress has been implicated in the development of maternal diabetes-induced neural tube defects (NTDs). ER stress-induced C/EBP homologous protein (CHOP) plays an important role in the pro-apoptotic execution pathways. However, the molecular mechanism underlying ER stress-...

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Bibliografske podrobnosti
izdano v:Toxicol Sci
Main Authors: Chen, Xi, Zhong, Jianxiang, Dong, Daoyin, Liu, Gentao, Yang, Peixin
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
ER Stress in Diabetic Embryopathy
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837255/
https://ncbi.nlm.nih.gov/pubmed/28482072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx096
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