GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance

Genomic amplification of the androgen receptor (AR) is an established mechanism of antiandrogen resistance in prostate cancer. Here, we show that the magnitude of AR signaling output, independent of AR genomic alteration or expression level, also contributes to antiandrogen resistance, through upreg...

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Pubblicato in:eLife
Autori principali: Lee, Eugine, Wongvipat, John, Choi, Danielle, Wang, Ping, Lee, Young Sun, Zheng, Deyou, Watson, Philip A, Gopalan, Anuradha, Sawyers, Charles L
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Cancer Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336405/
https://ncbi.nlm.nih.gov/pubmed/30644358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41913
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