Disruption of Thioredoxin Reductase 1 Protects Mice from Acute Acetaminophen-Induced Hepatotoxicity through Enhanced NRF2 Activity

The critical importance of glutathione in mitigating the deleterious effects of electrophile generating drugs such as acetaminophen (APAP) is well established. However, the role of other antioxidant systems, such as that provided by thioredoxin, has not been extensively studied. Selenoprotein thiore...

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Bibliographic Details
Published in:Chem Res Toxicol
Main Authors: Patterson, Andrew D., Carlson, Bradley A., Li, Fei, Bonzo, Jessica A., Yoo, Min-Hyuk, Krausz, Kristopher W., Conrad, Marcus, Chen, Chi, Gonzalez, Frank J., Hatfield, Dolph L.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334300/
https://ncbi.nlm.nih.gov/pubmed/23697945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx4001013
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