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Regulation of HIF-1α Activity by Overexpression of Thioredoxin is Independent of Thioredoxin Reductase Status
Under hypoxic conditions, cells activate a transcriptional response mainly driven by hypoxia-inducible factors (HIFs). HIF-1α stabilization and activity are known to be regulated by thioredoxin 1 (Txn1), but how the thioredoxin system regulates the hypoxic response is unknown. By examining the effec...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Korea Society for Molecular and Cellular Biology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3887957/ https://ncbi.nlm.nih.gov/pubmed/23912593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10059-013-0121-y |
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