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Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism

Selenium is an essential trace element in mammals, but is toxic at high levels. It is best known for its cancer prevention activity, but cancer cells are more sensitive to selenite toxicity than normal cells. Since selenite treatment leads to oxidative stress, and the thioredoxin system is a major a...

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Detalhes bibliográficos
Main Authors: Tobe, Ryuta, Yoo, Min-Hyuk, Fradejas, Noelia, Carlson, Bradley A., Calvo, Soledad, Gladyshev, Vadim N., Hatfield, Dolph L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3508724/
https://ncbi.nlm.nih.gov/pubmed/22594686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120618
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