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Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism

Selenium is an essential trace element in mammals, but is toxic at high levels. It is best known for its cancer prevention activity, but cancer cells are more sensitive to selenite toxicity than normal cells. Since selenite treatment leads to oxidative stress, and the thioredoxin system is a major a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Tobe, Ryuta, Yoo, Min-Hyuk, Fradejas, Noelia, Carlson, Bradley A., Calvo, Soledad, Gladyshev, Vadim N., Hatfield, Dolph L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3508724/
https://ncbi.nlm.nih.gov/pubmed/22594686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120618
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