Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis

Thioredoxin reductase 1 (TR1) controls the redox state of protein thiols in mammalian cells and has been shown to have roles in both preventing and promoting cancer. To define the role of this selenoenzyme in hepatocellular carcinoma development, we examined tumor incidence in the liver of mice with...

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Autors principals: Carlson, Bradley A., Yoo, Min-Hyuk, Tobe, Ryuta, Mueller, Charles, Naranjo-Suarez, Salvador, Hoffmann, Victoria J., Gladyshev, Vadim N., Hatfield, Dolph L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514905/
https://ncbi.nlm.nih.gov/pubmed/22791808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs230
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