Targeting Thioredoxin Reductase 1 Reduction in Cancer Cells Inhibits Self-Sufficient Growth and DNA Replication

Thioredoxin reductase 1 (TR1) is a major redox regulator in mammalian cells. As an important antioxidant selenoprotein, TR1 is thought to participate in cancer prevention, but is also known to be over-expressed in many cancer cells. Numerous cancer drugs inhibit TR1, and this protein has been propos...

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Bibliografiske detaljer
Main Authors: Yoo, Min-Hyuk, Xu, Xue-Ming, Carlson, Bradley A., Patterson, Andrew D., Gladyshev, Vadim N., Hatfield, Dolph L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040202/
https://ncbi.nlm.nih.gov/pubmed/17971875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001112
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