Disruption of Thioredoxin Reductase 1 Protects Mice from Acute Acetaminophen-Induced Hepatotoxicity through Enhanced NRF2 Activity

The critical importance of glutathione in mitigating the deleterious effects of electrophile generating drugs such as acetaminophen (APAP) is well established. However, the role of other antioxidant systems, such as that provided by thioredoxin, has not been extensively studied. Selenoprotein thiore...

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Publicado en:Chem Res Toxicol
Autores principales: Patterson, Andrew D., Carlson, Bradley A., Li, Fei, Bonzo, Jessica A., Yoo, Min-Hyuk, Krausz, Kristopher W., Conrad, Marcus, Chen, Chi, Gonzalez, Frank J., Hatfield, Dolph L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334300/
https://ncbi.nlm.nih.gov/pubmed/23697945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx4001013
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