Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

The clinical benefit in patients with diverse types of metastatic cancers that is observed upon blockade of the PD-1 – PD-L1 interaction has highlighted the importance of this inhibitory axis in the suppression of tumor-specific T cell responses1–9. In spite of the key role of PD-L1 expression by ce...

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Publicado no:Nature
Main Authors: Mezzadra, Riccardo, Sun, Chong, Jae, Lucas T., Gomez-Eerland, Raquel, de Vries, Evert, Wu, Wei, Logtenberg, Meike E.W., Slagter, Maarten, Rozeman, Elisa A., Hofland, Ingrid, Broeks, Annegien, Horlings, Hugo M., Wessels, Lodewyk F. A., Blank, Christian U., Xiao, Yanling, Heck, Albert J.R., Borst, Jannie, Brummelkamp, Thijn R., Schumacher, Ton N.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333292/
https://ncbi.nlm.nih.gov/pubmed/28813410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23669
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