Φορτώνει......
ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain
KEY POINTS: Gain‐of‐function mutations in the highly selective Ca(2+) channel ORAI1 cause tubular aggregate myopathy (TAM) characterized by muscular pain, weakness and cramping. TAM‐associated mutations in ORAI1 first and third transmembrane domain facilitate channel opening by STIM1, causing consti...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Physiol |
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| Κύριοι συγγραφείς: | , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
John Wiley and Sons Inc.
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6332830/ https://ncbi.nlm.nih.gov/pubmed/30382595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277079 |
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