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ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain
KEY POINTS: Gain‐of‐function mutations in the highly selective Ca(2+) channel ORAI1 cause tubular aggregate myopathy (TAM) characterized by muscular pain, weakness and cramping. TAM‐associated mutations in ORAI1 first and third transmembrane domain facilitate channel opening by STIM1, causing consti...
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| 出版年: | J Physiol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6332830/ https://ncbi.nlm.nih.gov/pubmed/30382595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277079 |
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