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The Third Transmembrane Segment of Orai1 Protein Modulates Ca(2+) Release-activated Ca(2+) (CRAC) Channel Gating and Permeation Properties
Orai1, the pore subunit of Ca(2+) release-activated Ca(2+) channels, has four transmembrane segments (TMs). The first segment, TMI, lines the pore and plays an important role in channel activation and ion permeation. TMIII, on the other hand, does not line the pore but still regulates channel gating...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3186358/ https://ncbi.nlm.nih.gov/pubmed/21865174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265884 |
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