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The Third Transmembrane Segment of Orai1 Protein Modulates Ca(2+) Release-activated Ca(2+) (CRAC) Channel Gating and Permeation Properties

Orai1, the pore subunit of Ca(2+) release-activated Ca(2+) channels, has four transmembrane segments (TMs). The first segment, TMI, lines the pore and plays an important role in channel activation and ion permeation. TMIII, on the other hand, does not line the pore but still regulates channel gating...

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書誌詳細
主要な著者: Srikanth, Sonal, Yee, Ma-Khin Win, Gwack, Yousang, Ribalet, Bernard
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186358/
https://ncbi.nlm.nih.gov/pubmed/21865174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265884
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