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The Intracellular Loop of Orai1 Plays a Central Role in Fast Inactivation of Ca(2+) Release-activated Ca(2+) Channels
Store-operated Ca(2+) entry (SOCE) due to activation of Ca(2+) release-activated Ca(2+) (CRAC) channels leads to sustained elevation of cytoplasmic Ca(2+) and activation of lymphocytes. CRAC channels consisting of four pore-forming Orai1 subunits are activated by STIM1, an endoplasmic reticulum Ca(2...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2836109/ https://ncbi.nlm.nih.gov/pubmed/20007711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072736 |
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