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The Intracellular Loop of Orai1 Plays a Central Role in Fast Inactivation of Ca(2+) Release-activated Ca(2+) Channels

Store-operated Ca(2+) entry (SOCE) due to activation of Ca(2+) release-activated Ca(2+) (CRAC) channels leads to sustained elevation of cytoplasmic Ca(2+) and activation of lymphocytes. CRAC channels consisting of four pore-forming Orai1 subunits are activated by STIM1, an endoplasmic reticulum Ca(2...

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Bibliografske podrobnosti
Main Authors: Srikanth, Sonal, Jung, Hea-Jin, Ribalet, Bernard, Gwack, Yousang
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836109/
https://ncbi.nlm.nih.gov/pubmed/20007711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072736
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