In vivo and Cellular Trafficking of Acetalated Dextran Microparticles for Delivery of a Host-Directed Therapy for Salmonella enterica Serovar Typhi Infection

Previously we have encapsulated host-directed therapy AR-12 into acetalated dextran (Ace-DEX) microparticles (MPs) to mitigate drug toxicity and passively target phagocytic host cells. Herein, we have improved upon our initial emulsion-based formulation of Ace-DEX MPs encapsulating AR-12 (AR-12/MPs)...

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Bibliografske podrobnosti
izdano v:Mol Pharm
Main Authors: Johnson, Monica M., Collier, Michael A., Hoang, Ky V., Pino, Erica N., Gurysh, Elizabeth G., Gallovic, Matthew D., Zahid, Md. Shamim Hasan, Chen, Naihan, Schlesinger, Larry S., Gunn, John S., Bachelder, Eric M., Ainslie, Kristy M.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330710/
https://ncbi.nlm.nih.gov/pubmed/30296381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00802
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