In vivo and Cellular Trafficking of Acetalated Dextran Microparticles for Delivery of a Host-Directed Therapy for Salmonella enterica Serovar Typhi Infection

Previously we have encapsulated host-directed therapy AR-12 into acetalated dextran (Ace-DEX) microparticles (MPs) to mitigate drug toxicity and passively target phagocytic host cells. Herein, we have improved upon our initial emulsion-based formulation of Ace-DEX MPs encapsulating AR-12 (AR-12/MPs)...

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Détails bibliographiques
Publié dans:Mol Pharm
Auteurs principaux: Johnson, Monica M., Collier, Michael A., Hoang, Ky V., Pino, Erica N., Gurysh, Elizabeth G., Gallovic, Matthew D., Zahid, Md. Shamim Hasan, Chen, Naihan, Schlesinger, Larry S., Gunn, John S., Bachelder, Eric M., Ainslie, Kristy M.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330710/
https://ncbi.nlm.nih.gov/pubmed/30296381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00802
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