Subtype-specific regulatory network rewiring in acute myeloid leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of mutations in transcription factors, epigenetic regulators and signaling molecules. To determine how different mutant regulators establish AML subtype-specific transcriptional networks we performed a comprehensive global a...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Assi, Salam A., Imperato, Maria Rosaria, Coleman, Daniel J. L., Pickin, Anna, Potluri, Sandeep, Ptasinska, Anetta, Chin, Paulynn Suyin, Blair, Helen, Cauchy, Pierre, James, Sally R., Zacarias-Cabeza, Joaquin, Gilding, L. Niall, Beggs, Andrew, Clokie, Sam, Loke, Justin C., Jenkin, Phil, Uddin, Ash, Delwel, Ruud, Richards, Stephen J., Raghavan, Manoj, Griffiths, Michael J., Heidenreich, Olaf, Cockerill, Peter N., Bonifer, Constanze
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330064/
https://ncbi.nlm.nih.gov/pubmed/30420649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0270-1
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