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COPI-Mediated Nuclear Translocation of EGFRvIII Promotes STAT3 Phosphorylation and PKM2 Nuclear Localization

As a non-ligand-dependent activation protein, EGFRvIII is the most common mutant of EGFR, and its existence or especially its nuclear translocation in tumors can exacerbate the malignancy. Compared with the nuclear translocation of EGFR, which has been studied extensively, the specific mechanism by...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Zhang, Mingzhi, Sun, Haojie, Deng, Yue, Su, Ming, Wei, Shiruo, Wang, Peipei, Yu, Lanlan, Liu, Jinwen, Guo, Jinhai, Wang, Xuan, Han, Xu, He, Qihua, Shen, Li
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329918/
https://ncbi.nlm.nih.gov/pubmed/30662352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.28679
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