COPI-Mediated Nuclear Translocation of EGFRvIII Promotes STAT3 Phosphorylation and PKM2 Nuclear Localization

As a non-ligand-dependent activation protein, EGFRvIII is the most common mutant of EGFR, and its existence or especially its nuclear translocation in tumors can exacerbate the malignancy. Compared with the nuclear translocation of EGFR, which has been studied extensively, the specific mechanism by...

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Bibliografiske detaljer
Udgivet i:Int J Biol Sci
Main Authors: Zhang, Mingzhi, Sun, Haojie, Deng, Yue, Su, Ming, Wei, Shiruo, Wang, Peipei, Yu, Lanlan, Liu, Jinwen, Guo, Jinhai, Wang, Xuan, Han, Xu, He, Qihua, Shen, Li
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329918/
https://ncbi.nlm.nih.gov/pubmed/30662352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.28679
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