COPI-Mediated Nuclear Translocation of EGFRvIII Promotes STAT3 Phosphorylation and PKM2 Nuclear Localization

As a non-ligand-dependent activation protein, EGFRvIII is the most common mutant of EGFR, and its existence or especially its nuclear translocation in tumors can exacerbate the malignancy. Compared with the nuclear translocation of EGFR, which has been studied extensively, the specific mechanism by...

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Dettagli Bibliografici
Pubblicato in:Int J Biol Sci
Autori principali: Zhang, Mingzhi, Sun, Haojie, Deng, Yue, Su, Ming, Wei, Shiruo, Wang, Peipei, Yu, Lanlan, Liu, Jinwen, Guo, Jinhai, Wang, Xuan, Han, Xu, He, Qihua, Shen, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2019
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329918/
https://ncbi.nlm.nih.gov/pubmed/30662352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.28679
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