COPI-Mediated Nuclear Translocation of EGFRvIII Promotes STAT3 Phosphorylation and PKM2 Nuclear Localization

As a non-ligand-dependent activation protein, EGFRvIII is the most common mutant of EGFR, and its existence or especially its nuclear translocation in tumors can exacerbate the malignancy. Compared with the nuclear translocation of EGFR, which has been studied extensively, the specific mechanism by...

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Detalles Bibliográficos
Publicado en:Int J Biol Sci
Autores principales: Zhang, Mingzhi, Sun, Haojie, Deng, Yue, Su, Ming, Wei, Shiruo, Wang, Peipei, Yu, Lanlan, Liu, Jinwen, Guo, Jinhai, Wang, Xuan, Han, Xu, He, Qihua, Shen, Li
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329918/
https://ncbi.nlm.nih.gov/pubmed/30662352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.28679
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