EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma

EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein product that cannot bind ligand, but signals constitutively. Deducing how EGFRvIII causes transformation has been difficult because of autocrine and paracrine loops triggered by EGFRvIII alone or in heterodimers...

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Bibliographische Detailangaben
Hauptverfasser: Fan, Qi-Wen, Cheng, Christine, Gustafson, W. Clay, Charron, Elizabeth, Zipper, Petra, Wong, Robyn A., Chen, Justin, Lau, Jasmine, Knobbe-Thomsen, Christiane, Weller, Michael, Jura, Natalia, Reifenberger, Guido, Shokat, Kevan M., Weiss, William A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819146/
https://ncbi.nlm.nih.gov/pubmed/24135280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.09.004
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