Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter

Aberrant EGFR signaling strongly promotes glioma malignancy and treatment resistance. The most prevalent mutation, ΔEGFR/EGFRvIII, is an in-frame deletion of the extracellular domain, which occurs in more than 25% of glioblastomas and enhances growth and survival of tumor cells. Paradoxically, the s...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Latha, Khatri, Li, Ming, Chumbalkar, Vaibhav, Gururaj, Anupama, Hwang, YeoHyeon, Dakeng, Sumana, Sawaya, Raymond, Aldape, Kenneth, Cavenee, Webster K., Bogler, Oliver, Furnari, Frank B.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3802533/
https://ncbi.nlm.nih.gov/pubmed/22729867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27690
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