µLAS: Sizing of expanded trinucleotide repeats with femtomolar sensitivity in less than 5 minutes

We present µLAS, a lab-on-chip system that concentrates, separates, and detects DNA fragments in a single module. µLAS speeds up DNA size analysis in minutes using femtomolar amounts of amplified DNA. Here we tested the relevance of µLAS for sizing expanded trinucleotide repeats, which cause over 20...

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Publicado en:Sci Rep
Main Authors: Malbec, Rémi, Chami, Bayan, Aeschbach, Lorène, Ruiz Buendía, Gustavo A., Socol, Marius, Joseph, Pierre, Leïchlé, Thierry, Trofimenko, Evgeniya, Bancaud, Aurélien, Dion, Vincent
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328573/
https://ncbi.nlm.nih.gov/pubmed/30631115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36632-5
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