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Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation

Induction of differentiation is a therapeutic strategy in high-risk neuroblastoma, a childhood cancer of the sympathetic nervous system. Neuroblastoma differentiation requires transcriptional upregulation of neuronal genes. How this process is regulated at epigenetic levels is not well understood. H...

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Détails bibliographiques
Publié dans:Oncogenesis
Auteurs principaux: Yang, Liqun, Zha, Yunhong, Ding, Jane, Ye, Bingwei, Liu, Mengling, Yan, Chunhong, Dong, Zheng, Cui, Hongjuan, Ding, Han-Fei
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328563/
https://ncbi.nlm.nih.gov/pubmed/30631055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-018-0112-0
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