The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma

BACKGROUND: Epigenetic alterations, such as histone methylation, modulate Myc signaling, a pathway central to oncogenesis. We investigated the role of the histone demethylase KDM4B in N-Myc–mediated neuroblastoma pathogenesis. METHODS: Spearman correlation was performed to correlate MYCN and KDM4B e...

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Publicat a:J Natl Cancer Inst
Autors principals: Yang, Jun, AlTahan, Alaa M., Hu, Dongli, Wang, Yingdi, Cheng, Pei-Hsin, Morton, Christopher L., Qu, Chunxu, Nathwani, Amit C., Shohet, Jason M., Fotsis, Theodore, Koster, Jan, Versteeg, Rogier, Okada, Hitoshi, Harris, Adrian L., Davidoff, Andrew M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555638/
https://ncbi.nlm.nih.gov/pubmed/25925418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv080
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