Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc

Glioblastoma is the most lethal brain tumor and its pathogenesis remains incompletely understood. KDM4C is a histone H3K9 demethylase that contributes to epigenetic regulation of both oncogene and tumor suppressor genes and is often overexpressed in human tumors, including glioblastoma. However, KDM...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Lee, Dong Hoon, Kim, Go Woon, Yoo, Jung, Lee, Sang Wu, Jeon, Yu Hyun, Kim, So Yeon, Kang, Hyeok Gu, Kim, Da-Hyun, Chun, Kyung-Hee, Choi, Junjeong, Kwon, So Hee
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814060/
https://ncbi.nlm.nih.gov/pubmed/33462212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03380-2
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