Advances in Histone Demethylase KDM3A as a Cancer Therapeutic Target

Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1 histone demethylases that promote gene expression. The KDM3 subfamily primarily consists of four proteins (KDM3A−D). All four proteins contain the catalytic Jumonji C domain (JmjC) at their C-termini, but whether KDM3C h...

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Bibliographische Detailangaben
Hauptverfasser: Jung Yoo, Yu Hyun Jeon, Ha Young Cho, Sang Wu Lee, Go Woon Kim, Dong Hoon Lee, So Hee Kwon
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-04-01
Schriftenreihe:Cancers
Schlagworte:
KDM3A
histone H3K9 demethylase
KDM3 inhibitor
anti-cancer agent
epigenetic agent
Online Zugang:https://www.mdpi.com/2072-6694/12/5/1098
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