KDM5A Regulates a Translational Program that Controls p53 Protein Expression

The p53 tumor suppressor pathway is frequently inactivated in human cancers. However, there are some cancer types without commonly recognized alterations in p53 signaling. Here we report that histone demethylase KDM5A is involved in the regulation of p53 activity. KDM5A is significantly amplified in...

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Gepubliceerd in:iScience
Hoofdauteurs: Hu, Dongli, Jablonowski, Carolyn, Cheng, Pei-Hsin, AlTahan, Alaa, Li, Chunliang, Wang, Yingdi, Palmer, Lance, Lan, Cuixia, Sun, Bingmei, Abu-Zaid, Ahmed, Fan, Yiping, Brimble, Mark, Gamboa, Nicolas T., Kumbhar, Ramhari C., Yanishevski, David, Miller, Kyle M., Kang, Guolian, Zambetti, Gerard P., Chen, Taosheng, Yan, Qin, Davidoff, Andrew M., Yang, Jun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214872/
https://ncbi.nlm.nih.gov/pubmed/30388705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.10.012
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