KDM5A Regulates a Translational Program that Controls p53 Protein Expression

The p53 tumor suppressor pathway is frequently inactivated in human cancers. However, there are some cancer types without commonly recognized alterations in p53 signaling. Here we report that histone demethylase KDM5A is involved in the regulation of p53 activity. KDM5A is significantly amplified in...

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Published in:iScience
Main Authors: Hu, Dongli, Jablonowski, Carolyn, Cheng, Pei-Hsin, AlTahan, Alaa, Li, Chunliang, Wang, Yingdi, Palmer, Lance, Lan, Cuixia, Sun, Bingmei, Abu-Zaid, Ahmed, Fan, Yiping, Brimble, Mark, Gamboa, Nicolas T., Kumbhar, Ramhari C., Yanishevski, David, Miller, Kyle M., Kang, Guolian, Zambetti, Gerard P., Chen, Taosheng, Yan, Qin, Davidoff, Andrew M., Yang, Jun
Format: Artigo
Language:Inglês
Published: Elsevier 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214872/
https://ncbi.nlm.nih.gov/pubmed/30388705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.10.012
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