Poly(ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions

The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have been identified, how KDM5A recognizes DNA lesion sites within chromatin is unknown. Here, we identify two factors that act upstr...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Cell Biol
Egile Nagusiak: Kumbhar, Ramhari, Sanchez, Anthony, Perren, Jullian, Gong, Fade, Corujo, David, Medina, Frank, Devanathan, Sravan K., Xhemalce, Blerta, Matouschek, Andreas, Buschbeck, Marcus, Buck-Koehntop, Bethany A., Miller, Kyle M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Rockefeller University Press 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135068/
https://ncbi.nlm.nih.gov/pubmed/34003252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202006149
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