Poly(ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions

The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have been identified, how KDM5A recognizes DNA lesion sites within chromatin is unknown. Here, we identify two factors that act upstr...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Kumbhar, Ramhari, Sanchez, Anthony, Perren, Jullian, Gong, Fade, Corujo, David, Medina, Frank, Devanathan, Sravan K., Xhemalce, Blerta, Matouschek, Andreas, Buschbeck, Marcus, Buck-Koehntop, Bethany A., Miller, Kyle M.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135068/
https://ncbi.nlm.nih.gov/pubmed/34003252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202006149
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