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Poly(ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions
The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have been identified, how KDM5A recognizes DNA lesion sites within chromatin is unknown. Here, we identify two factors that act upstr...
Gardado en:
| Publicado en: | J Cell Biol |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Rockefeller University Press
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8135068/ https://ncbi.nlm.nih.gov/pubmed/34003252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202006149 |
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