Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells

High-risk neuroblastoma remains one of the deadliest childhood cancers. Identification of metabolic pathways that drive or maintain high-risk neuroblastoma may open new avenues of therapeutic interventions. Here, we report the isolation and propagation of neuroblastoma sphere-forming cells with self...

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Detalhes bibliográficos
Main Authors: Mengling Liu, Yingfeng Xia, Jane Ding, Bingwei Ye, Erhu Zhao, Jeong-Hyeon Choi, Ahmet Alptekin, Chunhong Yan, Zheng Dong, Shuang Huang, Liqun Yang, Hongjuan Cui, Yunhong Zha, Han-Fei Ding
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016-10-01
Colecção:Cell Reports
Assuntos:
cancer metabolism
cholesterol biosynthesis
high-risk neuroblastoma
mevalonate pathway
MYCN
neuroblastoma stem cells
serine-glycine biosynthesis
statin
TH-MYCN mouse
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124716312438
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